Photomed Laser Surg. 2013 Apr;31(4):183-7. doi: 10.1089/pho.2012.3414. Epub 2013 Mar 8. A case report of conservative management of extensive proliferative verrucous leukoplakia using a carbon dioxide laser. Chainani-Wu N, Purnell DM, Silverman S Jr. Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA, USA. [email protected] Abstract OBJECTIVE: The purpose of this report was to describe a clinical case of conservative management of extensive proliferative verrucous leukoplakia (PVL) using a carbon dioxide laser, as an alternative to complete glossectomy, which led to a sustained successful outcome over a 12-year follow-up period. BACKGROUND DATA: Patients with oral PVL, a high […]

J Am Acad Dermatol. 2013 Jan;68(1):83-92. doi: 10.1016/j.jaad.2012.04.009. Epub 2012 May 8. Epidermolysis Bullosa Oropharyngeal Severity (EBOS) score: a multicenter development and reliability assessment. Fortuna G, Chainani-Wu N, Lozada-Nur F, Aria M, Cepeda-Valdes R, Pollio A, Marinkovich MP, Martinez-Salazar AE, Mignogna MD, Bruckner AL,Salas-Alanís JC. Source Department of Dermatology, Stanford University School of Medicine, Center for Clinical Sciences Research, Stanford, California 94305, USA. [email protected] Abstract BACKGROUND: Epidermolysis bullosa (EB) is a genetic mucocutaneous disorder characterized by blister formation upon mild trauma. All 4 EB types may show oropharyngeal lesions involving either hard or soft tissues. Currently, there are very few data on EB scoring that include the oropharyngeal cavity. OBJECTIVES: […]

Phytomedicine. 2012 Mar 15;19(5):418-23. doi: 10.1016/j.phymed.2011.11.005. Epub 2012 Feb 2. Use of curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease. Chainani-Wu N, Collins K, Silverman S Jr. Source Department of Orofacial Sciences, School of Dentistry, 521 Parnassus Ave, C646, Box 0658, University of California, San Francisco, CA 94143-0658, USA. [email protected] Abstract OBJECTIVES: To summarize long-term open-label use of curcuminoids and experience of side-effects in 53 patients with the autoimmune condition oral lichen planus (OLP) who had previously participated in randomized controlled trials (RCTs) of curcuminoids at UCSF. METHODS: This descriptive retrospective cohort study conducted in 2009 collected information […]

J Am Acad Dermatol. 2012 May;66(5):752-60. doi: 10.1016/j.jaad.2011.04.022. Epub 2011 Sep 9. High-dose curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus. Chainani-Wu N, Madden E, Lozada-Nur F, Silverman S Jr. Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, California 94143-0658, USA. [email protected] Abstract BACKGROUND: Curcuminoids are components of turmeric (Curcuma longa) that possess anti-inflammatory properties. OBJECTIVE: We sought to study the efficacy of curcuminoids in controlling the signs and symptoms of oral lichen planus, at doses of 6000 mg/d (3 divided doses), and their safety at this dose. METHODS: Twenty consecutive, eligible patients […]

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Aug;112(2):203-8. doi: 10.1016/j.tripleo.2011.03.014. A case-control study of burning mouth syndrome and sleep dysfunction. Chainani-Wu N, Madden E, Silverman S Jr. Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, CA, USA. [email protected] Abstract OBJECTIVE: The objective of this study was to evaluate whether sleep dysfunction is a risk factor for burning mouth syndrome (BMS). STUDY DESIGN: An age- and sex-matched case-control study of patients with BMS and controls with various oral conditions was conducted. A numerical rating scale for oral discomfort and the sleep scale from the medical outcomes study […]

Am J Cardiol. 2011 Aug 15;108(4):498-507. doi: 10.1016/j.amjcard.2011.03.077. Epub 2011 May 31. Changes in emerging cardiac biomarkers after an intensive lifestyle intervention. Chainani-Wu N, Weidner G, Purnell DM, Frenda S, Merritt-Worden T, Pischke C, Campo R, Kemp C, Kersh ES, Ornish D. Source Preventive Medicine Research Institute, Sausalito, California, USA. [email protected] Abstract The present study evaluated the changes in emerging cardiac biomarkers, cognitive function, and social support measures after a comprehensive lifestyle intervention that included a low-fat, whole-foods, plant-based diet, exercise, stress management, and group support meetings. We conducted a prospective cohort study of 131 participants (59.2% women and 43.1% with diabetes mellitus), 56 with coronary heart disease (CHD) (37.5% women […]

J Am Dent Assoc. 2011 Feb;142(2):166-9. Diet and prevention of oral cancer: strategies for clinical practice. Chainani-Wu N, Epstein J, Touger-Decker R. Source Department of Orofacial Sciences, School of Dentistry, University of California, San Francisco, USA. [email protected] Abstract BACKGROUND: Oral health care professionals can play an important role in preventing oral cancer by performing oral mucosal examinations to detect pre-cancerous changes and by educating patients about oral cancer prevention strategies, including dietary approaches. CONCLUSIONS: Current evidence supports a diet high in fruits, vegetables and plant-based foods for prevention of oral cancer. Dietary supplements-including vitamins and minerals-have not been shown to be effective as substitutes […]

Am J Cardiol. 2010 Jun 1;105(11):1570-6. doi: 10.1016/j.amjcard.2010.01.016. Epub 2010 Apr 10. Relation of B-type natriuretic peptide levels to body mass index after comprehensive lifestyle changes. Chainani-Wu N, Weidner G, Purnell DM, Frenda S, Merritt-Worden T, Kemp C, Kersh E, Ornish D. Source Preventive Medicine Research Institute, Sausalito, California; University of California, San Francisco, California, USA. [email protected] Abstract Cross-sectional studies have reported inverse associations of B-type natriuretic peptide (BNP) with the body mass index (BMI). We evaluated whether changes in the BMI are associated with changes in BNP. A nested prospective cohort study of a lifestyle intervention (low-fat, whole-foods diet, exercise, stress management, and social support) was conducted. BNP, […]

J Calif Dent Assoc. 2008 Oct;36(10):775-9. Immunosuppressants Chainani-Wu N, Wu TC. Source Orofacial Sciences Department, University of California, San Francisco, USA. Abstract This paper provides a brief introduction to some of the common immunosuppressants used in oral medicine, the prevention and treatment of oral adverse effects of immunosuppressants, and considerations for dental treatment in patients taking immunosuppressants. PMID:  19044098[PubMed – indexed for MEDLINE]

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jan;105(1):51-8. Validation of instruments to measure the symptoms and signs of oral lichen planus. Chainani-Wu N, Silverman S Jr, Reingold A, Bostrom A, Lozada-Nur F, Weintraub J. Source Department of Orofacial Sciences, University of California, San Francisco, CA 94143-0658, USA. [email protected] Abstract OBJECTIVE: The aim of this study was to validate the visual analog scale (VAS), numeric rating scale (NRS), and change in symptoms scale (CSS) in measuring symptoms of oral lichen planus, and the modified oral mucositis index (MOMI) in measuring the signs of oral lichen planus. STUDY DESIGN: Criterion validity, construct validity, and internal consistency […]