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Gingival leukoplakia, a premalignant condition, can pose difficulties to surgical access because of the presence of teeth and potential extensions into the periodontal ligament. We present a series of five patients with gingival leukoplakia who were treated with carbon dioxide laser vaporization. We describe lesion characteristics and recurrence patterns suggesting that presence of gingival leukoplakia on facial and palatal/lingual aspect through the interproximal areas may increase the risk of recurrence after conservative surgical removal.